Research Highlights

Publications

Prakash, A., Li, Z., Chirasani, V.R., Rasquinha, J.A., Hewitt, N., Hubbard, G.B., Yin, G., Hawkins, A.T., Montore, L.J., Dohlman, H.G., and Campbell, S.L. (2025) Molecular and functional profiling of Gαi as an intracellular pH sensor.��Nat Commun., 16, 3468. 10.1038/s41467-025-58323-2
Bereda, C.C., Dewey, E.B., Nasr, M.A., Chirasani, V.R., and Sekelsky, J. (2025) Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered Region. Genetics, iyaf005. 10.1093/genetics/iyaf005
Akçeşme, B., Hekimoğlu, H., Chirasani, V.R., İş, Ş., Atmaca, H.N., Waldern, J.M., and Ramos, S.B.V. (2025) Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2. RNA Biology, 22, 1–15. 10.1080/15476286.2024.2437590
Anyetei-Anum, C.S., Leatham-Jensen, M.P., Fox, G.C., Smith, B.R., Chirasani, V.R., Krajewski, K., Strahl, B.D., Dowen, J.M., Matera, A.G., Duronio, R.J., and McKay, D.J. (2024) Evidence for dual roles of histone H3 lysine-4 in antagonizing Polycomb group function and promoting target gene expression. Genes Dev., 38, 1033–1046. 10.1101/gad.350239.124
Lopez, A.G., Chirasani, V.R., Balan, I., O’Buckley, T.K., Adelman, M.R., and Morrow, A.L. (2024) Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling. Biomolecules, 14, 1441. 10.3390/biom14111441
Chirasani, V. R., Elferdink, M., Kral, M., Carter, J. S., Heitmann, S., Meissner, G., and Yamaguchi, N. (2023) Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel. Journal of Biological Chemistry. 10.1016/J.JBC.2023.105606
Petell, C. J., Burkholder, N. T., Ruiz, P. A., Skela, J., Foreman, J. R., Southwell, L. E., Temple, B. R., Krajewski, K., and Strahl, B. D. (2023) The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation. Journal of Biological Chemistry. 10.1016/j.jbc.2023.104996
Chappell, D. L., Sandhu, P. K., Wong, J. P., Bhatt, A. P., Liu, X., Buhrlage, S. J., Temple, B. R. S., Major, M. Ben, and Damania, B. (2023) KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle. J Virol. 10.1128/jvi.01763-22
Crain, A. T., Klusza, S., Armstrong, R. L., Santa Rosa, P., Temple, B. R. S., Strahl, B. D., McKay, D. J., Matera, A. G., and Duronio, R. J. (2022) Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster. Genetics. 10.1093/genetics/iyac054
Duncan, B. W., Mohan, V., Wade, S. D., Truong, Y., Kampov-Polevoi, A., Temple, B. R., and Maness, P. F. (2021) Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling. Mol Neurobiol. 58, 3817–3834
Peng, B., Temple, B. R., Yang, J., Geng, S., Culton, D. A., and Qian, Y. (2021) Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus. J Autoimmun. 10.1016/j.jaut.2020.102561
Verardi, R., Lindesmith, L. C., Tsybovsky, Y., Gorman, J., Chuang, G.-Y., Edwards, C. E., Brewer-Jensen, P. D., Mallory, M. L., Ou, L., Schön, A., Shi, W., Tully, E. S., Georgiou, G., Baric, R. S., and Kwong, P. D. (2020) Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes. NPJ Vaccines. 5, 110
Dee, R. A., Bai, X., Mack, C. P., and Taylor, J. M. (2020) Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo. Cells. 10.3390/cells9041042
Arrington, M. E., Temple, B., Schaefer, A., and Campbell, S. L. (2020) The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. Journal of Biological Chemistry. 295, 12130–12142
Sarker, M., Goliaei, A., Golesi, F., Poggi, M., Cook, A. A., Khan, M. A. I., Temple, B. R., Stefanini, L., Canault, M., Bergmeier, W., and Campbell, S. L. (2020) Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides. Journal of Thrombosis and Haemostasis. 18, 693–705
Raimer, A. C., Singh, S. S., Edula, M. R., Paris-Davila, T., Vandadi, V., Spring, A. M., and Matera, A. G. (2020) Temperature-sensitive spinal muscular atrophy-causing point mutations lead to SMN instability, locomotor defects and premature lethality in Drosophila. DMM Disease Models and Mechanisms. 10.1242/dmm.043307
Mohan, V., Sullivan, C. S., Guo, J., Wade, S. D., Majumder, S., Agarwal, A., Anton, E. S., Temple, B. S., and Maness, P. F. (2019) Temporal regulation of dendritic spines through NrCAM-Semaphorin3F receptor signaling in developing cortical pyramidal neurons. Cerebral Cortex. 29, 963–977
Zhu, C., Dukhovlinova, E., Council, O., Ping, L., Faison, E. M., Prabhu, S. S., Potter, E. L., Upton, S. L., Yin, G., Fay, J. M., Kincer, L. P., Spielvogel, E., Campbell, S. L., Benhabbour, S. R., Ke, H., Swanstrom, R., and Dokholyan, N. V. (2019) Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies. Nat Commun. 10.1038/s41467-019-08876-w
Yoshino, H., Yin, G., Kawaguchi, R., Popov, K. I., Temple, B., Sasaki, M., Kofuji, S., Wolfe, K., Kofuji, K., Okumura, K., Randhawa, J., Malhotra, A., Majd, N., Ikeda, Y., Shimada, H., Kahoud, E. R., Haviv, S., Iwase, S., Asara, J. M., Campbell, S. L., and Sasaki, A. T. (2019) Identification of lysine methylation in the core GTPase domain by GoMADScan. PLoS One. 10.1371/journal.pone.0219436
Kaur, G., Guruprasad, K., Temple, B. R. S., Shirvanyants, D. G., Dokholyan, N. V., and Pati, P. K. (2018) Structural complexity and functional diversity of plant NADPH oxidases. Amino Acids. 50, 79–94
Evangelista, F., Roth, A. J., Prisayanh, P., Temple, B. R., Li, N., Qian, Y., Culton, D. A., Liu, Z., Harrison, O. J., Brasch, J., Honig, B., Shapiro, L., and Diaz, L. A. (2018) Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. J Autoimmun. 89, 171–185
Bermejo, E., Alberto, M. F., Paul, D. S., Cook, A. A., Nurden, P., Sanchez Luceros, A., Nurden, A. T., and Bergmeier, W. (2018) Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp). Platelets. 29, 84–86
Pozo, P. N., Matson, J. P., Cole, Y., Kedziora, K. M., Grant, G. D., Temple, B., and Cook, J. G. (2018) Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication. Mol Biol Cell. 29, 2989–3002
Frazier-Bowers, S. A., and Vora, S. R. (2017) Genetic Disorders of Dental Development: Tales from the Bony Crypt. Curr Osteoporos Rep. 15, 9–17
Kennedy, L., Kaltenbrun, E., Greco, T. M., Temple, B., Herring, L. E., Cristea, I. M., and Conlon, F. L. (2017) Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis. PLoS Genet. 10.1371/journal.pgen.1007011
Sullivan, C. S., Kümper, M., Temple, B. S., and Maness, P. F. (2016) The neural cell adhesion molecule (NCAM) promotes clustering and activation of EphA3 receptors in GABAergic interneurons to induce ras homolog gene family, member a (RhoA)/Rho-associated protein kinase (ROCK)-mediated growth cone collapse. Journal of Biological Chemistry. 291, 26262–26272
McDaniel, S. L., Fligor, J. E., Ruan, C., Cui, H., Bridgers, J. B., DiFiore, J. V., Guo, A. H., Li, B., and Strahl, B. D. (2016) Combinatorial histone readout by the dual plant homeodomain (PHD) fingers of rco1 mediates Rpd3S chromatin recruitment and the maintenance of transcriptional fidelity. Journal of Biological Chemistry. 291, 14796–14802
Spahich, N. A., Vitko, N. P., Thurlow, L. R., Temple, B., and Richardson, A. R. (2016) Staphylococcus aureus lactate- and malate-quinone oxidoreductases contribute to nitric oxide resistance and virulence. Mol Microbiol. 100, 759–773
Danshina, P. V., Qu, W., Temple, B. R., Rojas, R. J., Miley, M. J., Machius, M., Betts, L., and O’Brien, D. A. (2016) Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme. Mol Hum Reprod. 22, 410–426
Chopra, S., Palencia, A., Virus, C., Schulwitz, S., Temple, B. R., Cusack, S., and Reader, J. (2016) Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent. Nat Commun. 10.1038/ncomms12928
Groh, B. S., Yan, F., Smith, M. D., Yu, Y., Chen, X., and Xiong, Y. (2016) The antiobesity factor WDTC 1 suppresses adipogenesis via the CRL 4 WDTC 1 E3 ligase . EMBO Rep. 17, 638–647
Zha, Z., Han, X. R., Smith, M. D., Lei, Q. Y., Guan, K. L., and Xiong, Y. (2016) Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discov. 10.1038/CELLDISC.2016.5
Bhatt, A. P., Wong, J. P., Weinberg, M. S., Host, K. M., Giffin, L. C., Buijnink, J., Van Dijk, E., Izumiya, Y., Kung, H. J., Temple, B. R. S., and Damania, B. (2016) A viral kinase mimics S6 kinase to enhance cell proliferation. Proc Natl Acad Sci U S A. 113, 7876–7881
Waldron, L., Steimle, J. D., Greco, T. M., Gomez, N. C., Dorr, K. M., Kweon, J., Temple, B., Yang, X. H., Wilczewski, C. M., Davis, I. J., Cristea, I. M., Moskowitz, I. P., and Conlon, F. L. (2016) The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 36, 262–275
Wang, X., Liu, J., Zhang, W., Stashko, M. A., Nichols, J., Miley, M. J., Norris-Drouin, J., Chen, Z., Machius, M., DeRyckere, D., Wood, E., Graham, D. K., Earp, H. S., Kireev, D., and Frye, S. V. (2016) Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett. 7, 1044–1049
Watson, K., Rossi, G., Temple, B., and Brennwald, P. (2015) Structural basis for recognition of the Sec4 Rab GTPase by its effector, the Lgl/tomosyn homologue, Sro7. Mol Biol Cell. 26, 3289–3300
Taylor, S. M., Parobek, C. M., De Conti, D. K., Kayentao, K., Coulibaly, S. O., Greenwood, B. M., Tagbor, H., Williams, J., Bojang, K., Njie, F., Desai, M., Kariuki, S., Gutman, J., Mathanga, D. P., Mårtensson, A., Ngasala, B., Conrad, M. D., Rosenthal, P. J., Tshefu, A. K., Moormann, A. M., Vulule, J. M., Doumbo, O. K., Ter Kuile, F. O., Meshnick, S. R., Bailey, J. A., and Juliano, J. J. (2015) Absence of putative artemisinin resistance mutations among Plasmodium falciparum in sub-Saharan Africa: A molecular epidemiologic study. Journal of Infectious Diseases. 211, 680–688
Rossi, G., Watson, K., Demonch, M., Temple, B., and Brennwald, P. (2015) In vitro reconstitution of Rab GTPase-dependent vesicle clustering by the yeast lethal giant larvae/tomosyn homolog, Sro7. Journal of Biological Chemistry. 290, 612–624
Urano, D., Dong, T., Bennetzen, J. L., and Jones, A. M. (2015) Adaptive evolution of signaling partners. Mol Biol Evol. 32, 998–1007
Wang, S., Jiang, B., Zhang, T., Liu, L., Wang, Y., Wang, Y., Chen, X., Lin, H., Zhou, L., Xia, Y., Chen, L., Yang, C., Xiong, Y., Ye, D., and Guan, K. L. (2015) Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 10.1371/journal.pbio.1002243
Terzo, E. A., Lyons, S. M., Poulton, J. S., Temple, B. R. S., Marzluff, W. F., and Duronio, R. J. (2015) Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body. Mol Biol Cell. 26, 1559–1574
Pancera, M., Zhou, T., Druz, A., Georgiev, I. S., Soto, C., Gorman, J., Huang, J., Acharya, P., Chuang, G. Y., Ofek, G., Stewart-Jones, G. B. E., Stuckey, J., Bailer, R. T., Joyce, M. G., Louder, M. K., Tumba, N., Yang, Y., Zhang, B., Cohen, M. S., Haynes, B. F., Mascola, J. R., Morris, L., Munro, J. B., Blanchard, S. C., Mothes, W., Connors, M., and Kwong, P. D. (2014) Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 514, 455–461
Dixit, G., Baker, R., Sacks, C. M., Torres, M. P., and Dohlman, H. G. (2014) Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast. Journal of Biological Chemistry. 289, 15052–15063
Xu, Y., Li, F., Lv, L., Li, T., Zhou, X., Deng, C. X., Guan, K. L., Lei, Q. Y. L., and Xiong, Y. (2014) Oxidative stress activates sirt2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res. 74, 3630–3642
Ren, J., Lin, C. P. C., Pathak, M. C., Temple, B. R. S., Nile, A. H., Mousley, C. J., Duncan, M. C., Eckert, D. M., Leiker, T. J., Ivanova, P. T., Myers, D. S., Murphy, R. C., Brown, H. A., Verdaasdonk, J., Bloom, K. S., Ortlund, E. A., Neiman, A. M., and Bankaitis, V. A. (2014) A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Mol Biol Cell. 25, 712–727
Burd, C. E., Liu, W., Huynh, M. V., Waqas, M. A., Gillahan, J. E., Clark, K. S., Fu, K., Martin, B. L., Jeck, W. R., Souroullas, G. P., Darr, D. B., Zedek, D. C., Miley, M. J., Baguley, B. C., Campbell, S. L., and Sharpless, N. E. (2014) Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 4, 1418–1429
Nile, A. H., Tripathi, A., Yuan, P., Mousley, C. J., Suresh, S., Wallace, I. M., Shah, S. D., Pohlhaus, D. T., Temple, B., Nislow, C., Giaever, G., Tropsha, A., Davis, R. W., St. Onge, R. P., and Bankaitis, V. A. (2014) PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nat Chem Biol. 10, 76–84
Montgomery, E. R., Temple, B. R. S., Peters, K. A., Tolbert, C. E., Booker, B. K., Martin, J. W., Hamilton, T. P., Tagliatela, A. C., Smolski, W. C., Rogers, S. L., Jones, A. M., and Meigs, T. E. (2014) Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation. Mol Pharmacol. 85, 586–597
Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B. R., Velazquez-Campoy, A., Cusack, S., and Reader, J. S. (2013) Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase. Nat Commun. 10.1038/ncomms2421
Pancera, M., Shahzad-Ul-Hussan, S., Doria-Rose, N. A., McLellan, J. S., Bailer, R. T., Dai, K., Loesgen, S., Louder, M. K., Staupe, R. P., Yang, Y., Zhang, B., Parks, R., Eudailey, J., Lloyd, K. E., Blinn, J., Alam, S. M., Haynes, B. F., Amin, M. N., Wang, L. X., Burton, D. R., Koff, W. C., Nabel, G. J., Mascola, J. R., Bewley, C. A., and Kwong, P. D. (2013) Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat Struct Mol Biol. 20, 804–813
Bosch, D. E., Kimple, A. J., Muller, R. E., Giguère, P. M., Machius, M., Willard, F. S., Temple, B. R. S., and Siderovski, D. P. (2012) Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica. PLoS Pathog. 10.1371/journal.ppat.1003040
Cherkis, K. A., Temple, B. R. S., Chung, E. H., Sondek, J., and Dangl, J. L. (2012) AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana. PLoS One. 10.1371/journal.pone.0042633
Urano, D., Jones, J. C., Wang, H., Matthews, M., Bradford, W., Bennetzen, J. L., and Jones, A. M. (2012) G protein activation without a GEF in the plant kingdom. PLoS Genet. 10.1371/journal.pgen.1002756
Tomberg, J., Temple, B., Fedarovich, A., Davies, C., and Nicholas, R. A. (2012) A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: Mutational and computational analysis of PBP 2 from N. gonorrhoeae. Biochemistry. 51, 2775–2784
Jones, J. C., Jones, A. M., Temple, B. R. S., and Dohlman, H. G. (2012) Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins. Proc Natl Acad Sci U S A. 109, 7275–7279
Lenz, J. D., Temple, B. R. S., and Miller, V. L. (2012) Evolution and virulence contributions of the autotransporter proteins yapj and yapk of Yersinia pestis CO92 and their homologs in Y. pseudotuberculosis IP32953. Infect Immun. 80, 3693–3705
Jones, J. C., Duffy, J. W., Machius, M., Temple, B. R. S., Dohlman, H. G., and Jones, A. M. (2011) The crystal structure of a self-activating g protein α subunit reveals its distinct mechanism of signal initiation. Sci Signal. 10.1126/SCISIGNAL.2001446
Jones, J. C., Temple, B. R. S., Jones, A. M., and Dohlman, H. G. (2011) Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from arabidopsis thaliana. Journal of Biological Chemistry. 286, 13143–13150
Friedman, E. J., Wang, H. X., Jiang, K., Perovic, I., Deshpande, A., Pochapsky, T. C., Temple, B. R. S., Hicks, S. N., Harden, T. K., and Jones, A. M. (2011) Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein β subunit in Arabidopsis. Journal of Biological Chemistry. 286, 30107–30118
Hamel, B., Monaghan-Benson, E., Rojas, R. J., Temple, B. R. S., Marston, D. J., Burridge, K., and Sondek, J. (2011) SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. Journal of Biological Chemistry. 286, 12141–12148
Wu, H., and Brennwald, P. (2010) The Function of Two Rho Family GTPases Is Determined by Distinct Patterns of Cell Surface Localization. Mol Cell Biol. 30, 5207–5217
Buznikov, G. A., Nikitina, L. A., Bezuglov, V. V., Francisco, M. E. Y., Boysen, G., Obispo-Peak, I. N., Peterson, R. E., Weiss, E. R., Schuel, H., Temple, B. R. S., Morrow, A. L., and Lauder, J. M. (2010) A putative “pre-nervous” endocannabinoid system in early echinoderm development. Dev Neurosci. 32, 1–18
Temple, B. R. S., Jones, C. D., and Jones, A. M. (2010) Evolution of a signaling nexus constrained by protein interfaces and conformational states. PLoS Comput Biol. 10.1371/JOURNAL.PCBI.1000962
Wu, H., Turner, C., Gardner, J., Temple, B., and Brennwald, P. (2010) The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis. Mol Biol Cell. 21, 430–442
Kwak, Y. T., Raney, A., Kuo, L. S., Denial, S. J., Temple, B. R. S., Garcia, J. V., and Foster, J. L. (2010) Self-association of the Lentivirus protein, Nef. Retrovirology. 10.1186/1742-4690-7-77
Kesner, B. A., Milgram, S. L., Temple, B. R. S., and Dokholyan, N. V. (2010) Isoform divergence of the filamin family of proteins. Mol Biol Evol. 27, 283–295
Kesner, B. A., Ding, F., Temple, B. R., and Dokholyan, N. V. (2010) N-terminal strands of filamin Ig domains act as a conformational switch under biological forces. Proteins: Structure, Function and Bioinformatics. 78, 12–24
Mudgil, Y., Uhrig, J. F., Zhou, J., Temple, B., Jiang, K., and Jones, A. M. (2009) Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell. 21, 3591–3609
Heenan, E. J., Vanhooke, J. L., Temple, B. R., Betts, L., Sondek, J. E., and Dohlman, H. G. (2009) Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway. Biochemistry. 48, 6390–6401
Kimple, A. J., Soundararajan, M., Hutsell, S. Q., Roos, A. K., Urban, D. J., Setola, V., Temple, B. R. S., Roth, B. L., Knapp, S., Willard, F. S., and Siderovski, D. P. (2009) Structural determinants of G-protein α subunit selectivity by regulator of G-protein signaling 2 (RGS2). Journal of Biological Chemistry. 284, 19402–19411
Palmer, S. M., Playford, M. P., Craig, S. W., Schaller, M. D., and Campbell, S. L. (2009) Lipid binding to the tail domain of vinculin. Specificity and the role of the N and C termini. Journal of Biological Chemistry. 284, 7223–7231
Teotico, D. G., Frazier, M. L., Ding, F., Dokholyan, N. V., Temple, B. R. S., and Redinbo, M. R. (2008) Active nuclear receptors exhibit highly correlated AF-2 domain motions. PLoS Comput Biol. 10.1371/JOURNAL.PCBI.1000111
Kostelansky, M. S., Lounes, K. C., Ping, L. F., Dickerson, S. K., Gorkun, O. V., and Lord, S. T. (2007) Probing the γ2 calcium-binding site: Studies with γD298,301A fibrinogen reveal changes in the γ294-301 loop that alter the integrity of the “a” polymerization site. Biochemistry. 46, 5114–5123
Avellar, M. C. W., Honda, L., Hamil, K. G., Radhakrishnan, Y., Yenugu, S., Grossman, G., Petrusz, P., French, F. S., and Hall, S. H. (2007) Novel aspects of the sperm-associated antigen 11 (SPAG11) gene organization and expression in cattle (Bos taurus). Biol Reprod. 76, 1103–1116
Temple, B. R. S., and Jones, A. M. (2007) The plant heterotrimeric G-protein complex. Annu Rev Plant Biol. 58, 249–266
Brenman, J. E., and Temple, B. R. S. (2007) Opinion: Alternative views of AMP-activated protein kinase. Cell Biochem Biophys. 47, 321–331
Ryan, M. M., Temple, B. R. S., Phillips, S. E., and Bankaitis, V. A. (2007) Conformational dynamics of the major yeast phosphatidylinositol transfer protein Sec14p: Insight into the mechanisms of phospholipid exchange and diseases of Sec14p-like protein deficiencies. Mol Biol Cell. 18, 1928–1942
Paul, J. J., Kircus, S. R., Sorrell, T. N., Ropp, P. A., and Thorp, H. H. (2006) Effects of coordinating metal ions on the mediated inhibition of trypsin by bis(benzimidazoles) and related compounds. Inorg Chem. 45, 5126–5135
Chen, J. G., Ullah, H., Temple, B., Liang, J., Guo, J., Alonso, J. M., Ecker, J. R., and Jones, A. M. (2006) RACK1 mediates multiple hormone responsiveness and developmental processes in Arabidopsis. J Exp Bot. 57, 2697–2708
Fouché, N., Cesare, A. J., Willcox, S., Özgür, S., Compton, S. A., and Griffith, J. D. (2006) The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats. Journal of Biological Chemistry. 281, 37486–37495
Fan, C. Y., Ren, H. Y., Lee, P., Caplan, A. J., and Cyr, D. M. (2005) The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj. Journal of Biological Chemistry. 280, 695–702
Kostelansky, M. S., Lounes, K. C., Ping, L. F., Dickerson, S. K., Gorkun, O. V., and Lord, S. T. (2004) Calcium-Binding Site β2, Adjacent to the “b” Polymerization Site, Modulates Lateral Aggregation of Protofibrils during Fibrin Polymerization. Biochemistry. 43, 2475–2483
Kostelansky, M. S., Bolliger-Stucki, B., Betts, L., Gorkun, O. V., and Lord, S. T. (2004) BβGlu397 and BβAsp398 but Not BβAsp432 Are Required for “B:b” Interactions. Biochemistry. 43, 2465–2474
Paing, M. M., Temple, B. R. S., and Trejo, J. A. (2004) A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated reeeptor-1: Multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. Journal of Biological Chemistry. 279, 21938–21947
Dunty, J. M., Gabarra-Niecko, V., King, M. L., Ceccarelli, D. F. J., Eck, M. J., and Schaller, M. D. (2004) FERM Domain Interaction Promotes FAK Signaling. Mol Cell Biol. 24, 5353–5368
Gidwitz, S., Temple, B., and White, G. C. (2004) Mutations in and near the second calcium-binding domain of integrin αIIb affect the structure and function of integrin αIIbβ3. Biochemical Journal. 379, 449–459
Lyford, L. K., Sproul, A. D., Eddins, D., McLaughlin, J. T., and Rosenberg, R. L. (2003) Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors. Mol Pharmacol. 64, 650–658
Ullah, H., Chen, J. G., Temple, B., Boyes, D. C., Alonso, J. M., Davis, K. R., Ecker, J. R., and Jones, A. M. (2003) The β-subunit of the arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes. Plant Cell. 15, 393–409
Hamil, K. G., Liu, Q., Sivashanmugam, P., Anbalagan, M., Yenugu, S., Soundararajan, R., Grossman, G., Rao, A. J., Birse, C. E., Ruben, S. M., Richardson, R. T., Zhang, Y. L., O’Rand, M. G., Petrusz, P., French, F. S., and Hall, S. H. (2003) LCN6, a novel human epididymal lipocalin. Reproductive Biology and Endocrinology. 10.1186/1477-7827-1-112
Yenugu, S., Hamil, K. G., Birse, C. E., Ruben, S. M., French, F. S., and Hall, S. H. (2003) Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli. Biochemical Journal. 372, 473–483
Slessareva, J. E., Ma, H., Depree, K. M., Flood, L. A., Bae, H., Cabrera-Vera, T. M., Hamm, H. E., and Graber, S. G. (2003) Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling. Journal of Biological Chemistry. 278, 50530–50536
Hamil, K. G., Liu, Q., Sivashanmugam, P., Yenugu, S., Soundararajan, R., Grossman, G., Richardson, R. T., Zhang, Y. L., O’Rand, M. G., Petrusz, P., French, F. S., and Hall, S. H. (2002) Cystatin 11: A new member of the cystatin type 2 family. Endocrinology. 143, 2787–2796
Booden, M. A., Campbell, S. L., and Der, C. J. (2002) Critical but Distinct Roles for the Pleckstrin Homology and Cysteine-Rich Domains as Positive Modulators of Vav2 Signaling and Transformation. Mol Cell Biol. 22, 2487–2497
Gavin, D. K., Young, S. M., Xiao, W., Temple, B., Abernathy, C. R., Pereira, D. J., Muzyczka, N., and Samulski, R. J. (1999) Charge-to-Alanine Mutagenesis of the Adeno-Associated Virus Type 2 Rep78/68 Proteins Yields Temperature-Sensitive and Magnesium-Dependent Variants. J Virol. 73, 9433–9445

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