{"id":12275,"date":"2022-11-17T14:10:36","date_gmt":"2022-11-17T19:10:36","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=12275"},"modified":"2022-11-17T14:11:47","modified_gmt":"2022-11-17T19:11:47","slug":"dr-keriayn-smith-selected-as-hypothesis-fund-seed-grant-recipient","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/dr-keriayn-smith-selected-as-hypothesis-fund-seed-grant-recipient\/","title":{"rendered":"Dr. Keriayn Smith Selected as Hypothesis Fund Seed Grant Recipient"},"content":{"rendered":"

Keriayn Smith, PhD, Assistant Professor in the Department of Genetics, was selected as one of six inaugural recipients of grants from the Hypothesis Fund to advance early-stage innovative research.<\/p>\n

\n
<\/figcaption><\/figure>\n
\"Keriayn
Keriayn Smith, PhD<\/figcaption><\/figure>\n

Keriayn Smith, PhD, Assistant Professor in the 大象传媒 Department of Genetics at the 大象传媒, was selected among six scientists to receive an inaugural seed grant<\/a>\u00a0from the Hypothesis Fund, a new initiative dedicated to \u201cadvancing scientific knowledge by supporting early stage, innovative research that increases our adaptability against systemic risks to the health of people and the planet.\u201d<\/p>\n

Smith\u2019s project, titled, \u201cNot Junk: Noncoding RNAs as Determinants of Cell Identity,\u201d was selected for the boldness of the science, her willingness to take risk and go after a big idea, and the potential long-term impact of her work.<\/p>\n

The Hypothesis Fund<\/a>\u00a0takes a unique approach to supporting research. It empowers a diverse, world-class network of scientist scouts to identify the high-risk, high-reward ideas at the edge of the network that would otherwise be underfunded or not pursued at all.<\/p>\n

The Hypothesis Fund, founded by\u00a0David Sanford<\/a>, supports research projects at their earliest stages, typically before there is any preliminary data. \u201cOur funding is intended to be catalytic \u2013 a fast path to enable a scientist to \u2018turn over the card\u2019 and see what\u2019s there,\u201d Sanford said. \u201cAnd we focus on bold new ideas in basic research, not continuations of existing research.\u201d<\/p>\n

Smith\u2019s lab will use single cell\/molecule and computational approaches to shed light on the importance of vastly understudied RNAs, to support a goal of defining roles for specific noncoding transcripts in developmental decisions in cells.<\/p>\n

From Dr. Smith\u2019s project abstract:<\/em><\/p>\n

Most of the human genome does not directly code for protein important for specific functions inside cells. Less than 3% of the genome encodes messenger RNAs, and yet there is pervasive transcription to produce thousands of RNAs. This includes a myriad noncoding RNAs that are uncharacterized or understudied. The long noncoding RNA (lncRNA) class of RNAs are processed similar to mRNAs, and are thought to outnumber mRNAs in the human genome. While the field has grown exponentially over the past decade, only a small fraction of human lncRNAs (of ~20,000 human genes and ~60,000 transcripts) are well-understood.<\/p>\n

However, the lncRNAs characterized experimentally thus far have important functions. These include influencing cellular processes such as transcription, splicing, and translation regulation, to impact cellular homeostasis and cell identity. Additionally, it is increasingly appreciated that many disease-causing SNPs are in noncoding regions of the genome that have the potential to produce lncRNAs. This, together with striking cell- and tissue-specific expression relative to mRNAs, suggests potential roles for lncRNAs in development and disease, including degenerative diseases and cancers.<\/p>\n

\u201cOur project will bring a new dimension to the vast body of \u2018omics data by filling gaps that cannot be fully explained by bulk or protein-centric analyses,\u201d Smith said. \u201cGiven the sheer numbers of lncRNAs, our project has the potential to add an entire dimension of knowledge to contribute to regenerative & personalized medicine approaches, including gene-therapy and theranostic development.<\/p>\n

Along with Dr. Smith\u2019s basic science interests she serves as the Director of Training & Excellence of the newly launched\u00a0RNA Discovery Center<\/a>\u00a0at the 大象传媒 Lineberger Comprehensive Cancer Center, with a goal of increasing the diversity of scientists who study RNA. This is supported by a longstanding track-record of designing and executing programs that have impacted thousands of individuals at varying educational levels.<\/p>\n

 <\/p>\n

This article originally appeared in the 大象传媒 Health Newsroom.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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