{"id":12821,"date":"2023-05-03T10:35:43","date_gmt":"2023-05-03T14:35:43","guid":{"rendered":"https:\/\/www.med.unc.edu\/genetics\/?p=12821"},"modified":"2023-05-03T10:35:43","modified_gmt":"2023-05-03T14:35:43","slug":"dr-mark-heise-inks-deal-with-moderna-therapeutics-to-develop-improved-models-to-study-vaccine-safety-and-immunogenicity","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/genetics\/dr-mark-heise-inks-deal-with-moderna-therapeutics-to-develop-improved-models-to-study-vaccine-safety-and-immunogenicity\/","title":{"rendered":"Dr. Mark Heise Inks Deal with Moderna Therapeutics to Develop Improved Models to Study Vaccine Safety and Immunogenicity"},"content":{"rendered":"<figure id=\"attachment_9368\" class=\"thumbnail wp-caption alignright\" style=\"width: 232px\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9368\" src=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2020\/10\/Mark-Heise-e1601562562304.jpg\" alt=\"Mark Heise\" width=\"222\" height=\"222\" srcset=\"https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2020\/10\/Mark-Heise-e1601562562304.jpg 365w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2020\/10\/Mark-Heise-e1601562562304-300x300.jpg 300w, https:\/\/www.med.unc.edu\/genetics\/wp-content\/uploads\/sites\/481\/2020\/10\/Mark-Heise-e1601562562304-150x150.jpg 150w\" sizes=\"auto, (max-width: 222px) 100vw, 222px\" \/><figcaption class=\"caption wp-caption-text\">Mark Heise, PhD (Professor, Genetics and Microbiology &amp; Immunology)<\/figcaption><\/figure>\n<p class=\"lead\">Mark Heise, PhD (Professor, Genetics and Microbiology &amp; Immunology) was awarded a scientific research agreement from Moderna Therapeutics to utilize the Collaborative Cross (CC) to improve models to study the safety and immunogenicity of vaccines.<\/p>\n<p>Specifically, the project will test a panel of CC strains for variation in mRNA vaccine-induced signs of reactogenicity, including local swelling, inflammation, inflammatory disease signs (e.g., cytokines) or systemic disease.\u00a0 Since reactogenicity has been linked to the magnitude of vaccine response, Heise will also evaluate whether reactogenicity is associated with variation in the magnitude or durability of vaccine-induced immunity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mark Heise, PhD (Professor, Genetics and Microbiology &amp; Immunology) was awarded a scientific research agreement from Moderna Therapeutics to utilize the Collaborative Cross (CC) to improve models to study the safety and immunogenicity of vaccines.\u00a0<\/p>\n","protected":false},"author":28418,"featured_media":9368,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[100],"class_list":["post-12821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-heise","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dr. Mark Heise Inks Deal with Moderna Therapeutics to Develop Improved Models to Study Vaccine Safety and Immunogenicity | Department of Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/genetics\/dr-mark-heise-inks-deal-with-moderna-therapeutics-to-develop-improved-models-to-study-vaccine-safety-and-immunogenicity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Mark Heise Inks Deal with Moderna Therapeutics to Develop Improved Models to Study Vaccine Safety and Immunogenicity | Department of Genetics\" \/>\n<meta property=\"og:description\" content=\"Mark Heise, PhD (Professor, Genetics and Microbiology &amp; Immunology) was awarded a scientific research agreement from Moderna Therapeutics to utilize the Collaborative Cross (CC) to improve models to study the safety and immunogenicity of vaccines.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/genetics\/dr-mark-heise-inks-deal-with-moderna-therapeutics-to-develop-improved-models-to-study-vaccine-safety-and-immunogenicity\/\" \/>\n<meta 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