Nirupama Ramadas, PhD, Fatima Trebak, PhD, Rafal Pawlinski, PhD, and Erin Sparkenbaugh, PhD, with the 大象传媒 Division of Hematology, are co-authors of 鈥淏iased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease.” was accepted in Blood Advances, a journal of the American Society of Hematology.
The study shows APC inhibition exacerbates thrombin generation, inflammation and end-organ damage in a mouse model of sickle cell disease (SCD), and APC-PAR1 biased agonism reduces inflammation, suggesting that targeting this pathway may mitigate vascular complications of SCD.