Research Interests
- Phospholipase C and inositol lipid signaling
- P2Y receptors for extracellular nucleotides
- G proteins
Research Synopsis
The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.聽 聽A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity is modulated by receptor-activated heterotrimeric and Ras superfamily G proteins, as well as by tyrosine phosphorylation.聽 This work focuses on three PLC isozymes:聽(1) PLC-尾 isozymes, which are the prototypical heterotrimeric G protein-regulated PLCs, (2) PLC-蔚, which is uniquely directly activated by both Rho and Ras GTPases acting through independent domains, and (3) PLC-纬 isozymes, which are activated by phosphorylation by receptor and non-receptor tyrosine kinases.
Our research also focuses on mechanistic and pharmacological aspects of a class of G protein-coupled receptors (the eight member P2Y receptor family) that are activated by extracellular nucleotides.
