{"id":8488,"date":"2019-01-17T12:39:20","date_gmt":"2019-01-17T17:39:20","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?post_type=directory&#038;p=8488"},"modified":"2024-10-15T11:52:36","modified_gmt":"2024-10-15T15:52:36","slug":"t-kendall-harden-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/","title":{"rendered":"T. Kendall Harden, PhD"},"content":{"rendered":"<h3>Research Interests<\/h3>\n<ul>\n<li>Phospholipase C and inositol lipid signaling<\/li>\n<li>P2Y receptors for extracellular nucleotides<\/li>\n<li>G proteins<\/li>\n<\/ul>\n<h3>Research Synopsis<\/h3>\n<p>The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.\u00a0 \u00a0A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity is modulated by receptor-activated heterotrimeric and Ras superfamily G proteins, as well as by tyrosine phosphorylation.\u00a0 This work focuses on three PLC isozymes:\u00a0(1) PLC-\u03b2 isozymes, which are the prototypical heterotrimeric G protein-regulated PLCs, (2) PLC-\u03b5, which is uniquely directly activated by both Rho and Ras GTPases acting through independent domains, and (3) PLC-\u03b3 isozymes, which are activated by phosphorylation by receptor and non-receptor tyrosine kinases.<\/p>\n<p>Our research also focuses on mechanistic and pharmacological aspects of a class of G protein-coupled receptors (the eight member P2Y receptor family) that are activated by extracellular nucleotides.<\/p>\n<h3>Publications<\/h3>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=Harden+TK+[au]\" target=\"_blank\" rel=\"noopener noreferrer\"><i>Click here for a complete list of his publications (PubMed)<\/i><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Interests Phospholipase C and inositol lipid signaling P2Y receptors for extracellular nucleotides G proteins Research Synopsis The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.\u00a0 \u00a0A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity &hellip; <a href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\" aria-label=\"Read more about T. Kendall Harden, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":3478,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-8488","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T. Kendall Harden, PhD | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T. Kendall Harden, PhD | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Research Interests Phospholipase C and inositol lipid signaling P2Y receptors for extracellular nucleotides G proteins Research Synopsis The physiological responses of many hormones, neurotransmitters, growth factors, and other extracellular stimuli are mediated through phospholipase C (PLC)-catalyzed hydrolysis of membrane phosphoinositides.\u00a0 \u00a0A long-term goal of our research is to delineate the molecular mechanisms whereby PLC activity &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/大象传媒-Pharmacology-693103474191364\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-15T15:52:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pharm\/wp-content\/uploads\/sites\/930\/2018\/11\/ken-harden-2010-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pharm\/directory\/t-kendall-harden-phd\/\",\"name\":\"T. 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