{"id":19738,"date":"2022-12-08T15:31:10","date_gmt":"2022-12-08T20:31:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=19738"},"modified":"2023-01-17T15:22:34","modified_gmt":"2023-01-17T20:22:34","slug":"scientists-elucidate-how-dreadd-technology-highjacks-neuronal-activity","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/scientists-elucidate-how-dreadd-technology-highjacks-neuronal-activity\/","title":{"rendered":"Scientists Elucidate How DREADD Technology Highjacks Neuronal Activity"},"content":{"rendered":"

The 大象传媒 lab of Bryan L. Roth, MD, PhD, solved the high-resolution, complex structures of drug-like compounds bound to designer brain cell receptors, paving the way for the creation of next-generation chemogenetic tools. Postdoc Shicheng Zhang, PhD, led this research published in Nature.<\/p>\n

\"Shicheng
Shicheng Zhang, PhD<\/figcaption><\/figure>\n

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance abuse, epilepsy, and others.<\/p>\n

To both manipulate and understand this basic feature of neuronal biology, the lab of Bryan L. Roth, MD, PhD<\/a>, the Michael Hooker Distinguished Professor of Pharmacology at the 大象传媒, created a chemogenetic technology called DREADD \u2013 designer receptors exclusively activated by designer drugs \u2013 in the mid-2000s.\u00a0 Even though this technology is used ubiquitously in the neurosciences, why the technology was so efficient was unknown.<\/p>\n

Now, as reported in the journal Nature<\/em><\/a>, the Roth lab led by postdoctoral researcher Shicheng Zhang, PhD, used cryogenic electron microscopy to determine the detailed, high resolution structures of four DREADDs bound to three drug-like but inert compounds.<\/p>\n

\"Bryan
Bryan Roth, MD, PhD<\/figcaption><\/figure>\n

This work, made possible through the 大象传媒 CryoEM Core Facility<\/a>, reveals key details of DREADDs that should accelerate the structure-guided discovery of next-generation chemogenetic tools.<\/p>\n

\u201cAlthough DREADDs are widely used, the precise molecular basis for why they are so useful has been obscure until now,\u201d Zhang said. \u201cWe think these structures will help scientists around the world, including here at 大象传媒-Chapel Hill, investigate the development of more effective and safer therapeutics for a host of neuropsychiatric conditions.\u201d<\/p>\n

Get the full story in the original article by Mark Derewicz published in 大象传媒 Health Nov. 30, 2022 from which the above is just an excerpt to learn more about the development of DREADDs and this latest discovery!<\/a><\/em><\/p>\n

Read the Nature article to find out how they used cryogenic electron microscopy to determine the detailed structures of four DREADDs. It’s quite fascinating!<\/a><\/em><\/p>\n

Shicheng Zhang<\/b> is the lead author of the paper. Other authors are senior author Bryan Roth<\/strong>, Ryan Gumpper, X-P Huang, Yongfeng Liu, Brian Krumm and Can Cao<\/b>\u00a0and former TarHeel\u00a0Jonathan Fay<\/b>\u00a0from the University of Maryland School of Medicine.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

The Bryan Roth lab got some nice press for their recent Nature paper, revealing structural details of his chemogenetic technology called DREADD \u2013 designer receptors exclusively activated by designer drugs – that recognize drug-like but physiologically inert compounds. Postdoc Shicheng Zhang, PhD, led this research published in Nature.<\/p>\n","protected":false},"author":22429,"featured_media":19742,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[18,2,19],"tags":[],"class_list":["post-19738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty-news","category-news","category-student-postdoc-news","odd"],"acf":[],"yoast_head":"\nScientists Elucidate How DREADD Technology Highjacks Neuronal Activity | Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pharm\/scientists-elucidate-how-dreadd-technology-highjacks-neuronal-activity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Elucidate How DREADD Technology Highjacks Neuronal Activity | Pharmacology\" \/>\n<meta property=\"og:description\" content=\"The Bryan Roth lab got some nice press for their recent Nature paper, revealing structural details of his chemogenetic technology called DREADD \u2013 designer receptors exclusively activated by designer drugs - that recognize drug-like but physiologically inert compounds. 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