{"id":24752,"date":"2025-02-27T15:57:34","date_gmt":"2025-02-27T20:57:34","guid":{"rendered":"https:\/\/www.med.unc.edu\/pharm\/?p=24752"},"modified":"2025-03-11T16:32:52","modified_gmt":"2025-03-11T20:32:52","slug":"new-pagers-technology-builds-on-roth-labs-dreadds","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pharm\/new-pagers-technology-builds-on-roth-labs-dreadds\/","title":{"rendered":"New PAGERs technology builds on Roth lab’s DREADDs"},"content":{"rendered":"

Dr. Bryan Roth and his lab previously developed synthetic GPCRs called DREADDs. This technology has in turn laid the foundation for a new technology, PAGERs, which has an innovative approach to controlling cell activity. <\/p>\n

\"Bryan<\/p>\n

\u00a0DREADDs <\/strong>(Designer Receptors Exclusively Activated by Designer Drugs)<\/span> are synthetic GPCRs that are activated in cells or transgenic animals only when researchers administer a specific drug. The new technology, called <\/span>PAGERs <\/b>(Programmable Antigen-gated G-protein-coupled Engineered Receptors) provide modular, customizable G-protein-coupled receptors for cell-signalling studies.\u00a0<\/span><\/p>\n

The PAGERs <\/span>modular system developed by Alice Ting of Sanford) and Yulong Li (Peking University), builds on Roth\u2019s existing DREADDs technology.\u00a0 <\/span>Ting’s and Li’s paper \u201c<\/span>Synthetic GPCRs for programmable sensing and control of cell behaviour,\u201d was published in Nature in December 2024.<\/span><\/p>\n

The Nature article by Stephanie Melchor highlighting PAGERs includes an interview with Bryan Roth: “Build your own receptor: modular system can be tailored to any antigen”<\/em><\/a>\u00a0<\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

PAGERs, which has an innovative approach to controlling cell activity, was highlighted in Nature, including an interview with Bryan Roth<\/p>\n","protected":false},"author":22429,"featured_media":20166,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[18,2],"tags":[],"class_list":["post-24752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty-news","category-news","odd"],"acf":[],"yoast_head":"\nNew PAGERs technology builds on Roth lab's DREADDs | Pharmacology<\/title>\n<meta name=\"description\" content=\"A new technology, PAGERs, which has an innovative approach to controlling cell activity, builds on Roth lab's DREADDs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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